PENGARUH PEMBERIAN KOMBINASI KLORAMFENIKOL LUMBRICUS RUBELLUS TERHADAP KADAR SGOT DARAH PADA TIKUS YANG TERFEKSI SALMONELLA TYPHI

Typhoid fever can increase levels of SGOT. Drug of choice used were chloramphenicol. Lumbricus rubellus Lumbricin I which contain an antibacterial effect. The purpose of this study was to determine the effectiveness of the administration of the combination of chloramphenicol and Lumbricus rubellus in lowering blood SGOT levels in mice infected with Salmonella typhi compared with a single administration of chloramphenicol or Lumbricus rubellus. The study design was purely experimental. A total of 25 Rattus norvegicus tail Wister, divided 5 groups: no treatement group, negative group Salmonella typhi, chloramphenicol group, Lumbricus rubellus group, the combination group chloramphenicol - Lumbricus rubellus. Chloramphenicol dose 3.6 mg 4 times daily, a dose of L. rubellus 9mg therapy administered 3 times daily for 8 days and measured levels of SGOT. Data were analyzed using the Kruskal-Wallis followed Mann-Whitney. Average levels of SGOT is no treatment group, negative group Salmonella typhi, chloramphenicol group, Lumbricus rubellus group, the combination group chloramphenicol - Lumbricus rubellus. successively (18.708 ± 0.252), (29.016 ± 0.732), (23.810 ± 0.628), (21.926 ± 0.349), (21.412 ± 0.284). The results showed differences in the average levels were significant between all group. The combination of chloramphenicolLumbricus rubellus in lowering blood SGOT levels in mice infected with Salmonella typhi lower than a single administration of chloramphenicol or Lumbricus rubellus.