EFEK KO-KEMOTERAPI EKSTRAK BIJI PETAI (PARKIA SPECIOSA) DENGAN DOXORUBICIN TERHADAP TOKSISITAS SEL JANTUNG PADA TIKUS (SPRAGUE DAWLEY) MODEL KANKER LIDAH

Doxorubicin is widely used chemotherapy agent. However, its activity induces cardiotoxicity by iron-mediated free radicals formation. Co-chemotherapy which combine conventional chemotherapy such as Doxorubicin with herbal was expected to reduce cardiotoxicity. Petai seed extract (Parkia speciosa) contains flavonoid which were allegedly suitable co-chemotherapy agent for its properties as antioxidant and iron chelating agent. The purpose of this paper was to evaluate co-chemotherapy effect of petai seed (Parkia speciosa) extract with Doxorubicin against cardiotoxicity in tongue cancer rat (Sprague dawley) model.
42 rats were collected and divided into 6 groups. Group 1 is negavtive control, group 2-6 were given exposure to carcinogenic (4-NQO) as cancer models for 12 weeks. After 12 weeks, group 2-6 recieved treatment. Group 2 were given only aquades, Group 3 were given Doxorubicin 4,6mg/KgBW and Group 4, 5, 6 were given 100, 200, 400 mg/KgBW of petai seed extract (Parkia speciosa) combined with 4,6mg/KgBW of Doxorubicin. This treatment was perfomed for 14 days. In 14th week heart tissue of rats were necropted, stained using Hematoxylin-Eosin (HE) and observed. The damage was evaluated based on its precentage and damage scale.