MUHAMMAD HADIYAN RASYADI (2016) PENGARUH HIPOKSIA ISKEMIK PRENATAL TERHADAP UKURAN MIOKARDIUM TIKUS RATTUS NORVEGICUS GALUR SPRAGUE-DAWLEY. S1 thesis, Universitas Muhammadiyah Yogyakarta.
![[thumbnail of Cover]](https://etd.umy.ac.id/style/images/fileicons/text.png)
Cover.pdf
Download (15kB)
![[thumbnail of Halaman Judul]](https://etd.umy.ac.id/style/images/fileicons/text.png)
Halaman Judul.pdf
Download (268kB)
![[thumbnail of Lembar Pengesahan]](https://etd.umy.ac.id/style/images/fileicons/text.png)
Lembar Pengesahan.pdf
Download (1MB)
![[thumbnail of Abstract]](https://etd.umy.ac.id/style/images/fileicons/text.png)
Abstract.pdf
Download (14kB)
![[thumbnail of Bab I]](https://etd.umy.ac.id/style/images/fileicons/text.png)
Bab I.pdf
Download (274kB)
![[thumbnail of Bab II]](https://etd.umy.ac.id/style/images/fileicons/text.png)
Bab II.pdf
Restricted to Registered users only
Download (796kB)
![[thumbnail of Bab III]](https://etd.umy.ac.id/style/images/fileicons/text.png)
Bab III.pdf
Restricted to Registered users only
Download (293kB)
![[thumbnail of Bab IV]](https://etd.umy.ac.id/style/images/fileicons/text.png)
Bab IV.pdf
Restricted to Registered users only
Download (398kB)
![[thumbnail of Bab V]](https://etd.umy.ac.id/style/images/fileicons/text.png)
Bab V.pdf
Restricted to Registered users only
Download (6kB)
![[thumbnail of Daftar Pustaka]](https://etd.umy.ac.id/style/images/fileicons/text.png)
Daftar Pustaka.pdf
Download (115kB)
![[thumbnail of Naskah Publikasi]](https://etd.umy.ac.id/style/images/fileicons/text.png)
Naskah Publikasi.pdf
Download (515kB)
![[thumbnail of Lampiran]](https://etd.umy.ac.id/style/images/fileicons/text.png)
Lampiran.pdf
Restricted to Repository staff only
Download (39kB)
Abstract
Background: Hypoxia is a condition to the low concentration of oxygen in the cells or tissues that may threaten the survival of cells. Cells can adaptation, injury, or death. Prenatal hypoxia is still a major cause of morbidity and mortality in developed and developing countries based on datafrom World Health Organization (WHO). Oxygen is an important component in the metabolism of the myocardium. This study aimed to research the effect of prenatal hypoxic ischemic on thickness of myocardium. Methods: This research use experimental post -test control group design. This study used child Rattus norvegicus of Sprague-Dawley strain obtained from a pregnant female Rattus norvegicus who was induced until prenatal hypoxic ischemic happen in different age gestation by ligating the right uterina artery. Female Rattus norvegicus were divided into 3 groups, K is a control group that was not induced prenatal ischemic hypoxic, P1 group was given induced prenatal ischemic hypoxia on the parent who is pregnant at the age of 7 days, P2 group was given induced prenatal ischemic hypoxia on the parent who is pregnant at the age of 11 days. After that put the incision from the heartof the rat into the object glass and coloured it with Hematoxylin Eosin stain and then measured it under the microscope.
Result: Prenatal hypoxic ischemic induction shows changes in the size of the myocardium by increasing the size. One - Way ANOVA test showed a significant increase (p=0,000). Post Hoc test showed differences in the increase of the size of the heart myocardium significantly between groups K-P1(p=0,000), K-P2(p=0,000), P1-P2(p=0,097). Conclusion: There is a significant difference in the size of the thickness from the myocardium rats Rattus norvegicus strain Sprague - Dawley induced prenatal hypoxic ischemic by ligating right uterine artery between the intervention group and control group. There is an increased thickness of the myocardium according to the time of exposure, the earlier the exposure is given, will increase more significant influence.
Item Type: | Thesis (S1) |
---|---|
Uncontrolled Keywords: | HYPOXIA, ISCHEMIA, PRENATAL , SIZE OF THE MYOCARDIUM |
Divisions: | Fakultas Kedokteran > Kedokteran S1 |
Depositing User: | Unnamed user with email robi@umy.ac.id |
Date Deposited: | 15 Jan 2022 02:29 |
Last Modified: | 15 Jan 2022 02:29 |
URI: | https://etd.umy.ac.id/id/eprint/27851 |