HUBUNGAN EKSPRESI p53 DENGAN PROGNOSIS HASIL TERAPI RADIASI PADA KARSINOMA NASOFARING

In the cancer condition, there is increasing of cell proliferation than apoptosis, so cell will grow rapidly than normal. In normal homeostatic, to set the amount of the cells in human body, the primary body mechanism is producing gene p53. The p53 as protein cancer suppressor activate protein that role to activate some of complex kinase based on cyclin and cut mitosis cycle (Xiang et al, 1993). A study show that increased of p53 expression may inhibit carcinoma cell proliferation following by chemotherapy (Gartel dan Tyner, 2002). We analyzed relation p53 expression with prognosis of radiotherapy in nasopharingeal carcinoma. The research method is retrospective study. P53 expression has been imunohistochemistry strained and considered positive if we find greater than 10% positif cell tumor. We then analyzed relation p53 expression with prognosis of radiotherapy in nasopharingeal carcinoma. The result shows from 43 patient nasopharingeal carcinoma with radiotherapy there are 8 patient (18,6%) died. 74,42% patient are male and 25,58% are female. 51-60 years old group is 14 cases (32,56 %) greater than other group of age, there was significant correlation between prognosis and p53 expression p= 0,000 (p<0,05). The conclusion is our findings show that positive p53 expression will give a better prognostic for nasopharingeal carcinoma with radiotherapy.