PENGARUH EKSTRAK RAMBUT JAGUNG (ZEA MAYS L.) TERHADAP GAMBARAN HISTOLOGI GINJAL TIKUS PUTIH YANG DIINDUKSI ALKOHOL (STUDI IN VIVO PADA RATTUS NORVEGICUS)

Background: Alcohol contains ethanol, which is toxic, and it can increase oxidative stress. So, it has a bad impact for body health, including the kidneys. Oxidative stress can be prevented with antioxidants. Corn silk contains bioactive compounds in the form of flavonoids which have antioxidant effects. Aims: This study was aimed to determine the effect of corn silk extract on the histological picture of the kidneys of white rats induced by alcohol. Methods: This study was a pure experiment with a post-test only control group design using 36 rats divided into 9 groups. Consisting of a control group (C) which was given aquadest, a negative control (P) which was induced by alcohol 1 ml/day, a positive control group (J1, J2, J3) which was given corn silk extract at a dose of 50 mg/KgBW, 100 mg/KgBW, 150 mg/KgBW, the treatment group (PJ1, PJ2, PJ3) which was induced by alcohol 1 ml/day then given corn silk extract at a dose of 50 mg/KgBW, 100 mg/KgBW, 150 mg/KgBW and the comparison group (S) which alcohol induced 1 ml/day and given 1 ml of vitamin C solution. Histological damage to the renal cortex was assessed by a score of glomerular damage in the form of inflammatory cell infiltration, Bowman's spatium edema, necrosis and a score of renal tubular damage in the form of inflammatory cell infiltration, tubular epithelial swelling and tubular necrosis. The data obtained in the form of an average score of damage. Data were analyzed using One Way ANOVA statistical test. Results: The average score of kidney damage in group C = 43.35; P = 54.55; J1 = 46.75; J2 = 47.20; J3 = 46.45; PJ1 = 50.75; PJ2 = 46.35; PJ3 = 47.20; and S = 46.90. The mean scores of glomerular and tubular damages in group C were significantly different from group P. Groups C and P did not differ significantly against groups J1, J2, J3, PJ1, PJ2, PJ3, and S. Conclusion: The administration of corn silk extract (Zea mays L.) had no effect on the renal histology of alcohol-induced white rats (Rattus norvegicus) by observing the glomerulus and renal tubules.