EFEKTIVITAS EKSTRAK ECHINACEA SEBELUM DIINFEKASI PLASMODIUM BERGHEI TERHADAP GAMBARAN HISTOLOGI OTAK MUSMUSCULUS

Malaria is a tropical infection which has a lot of attention from the global world as a high prevalence rate of occurrence. One of the problems encountered in the treatment of malaria effort is the emergence of resistance to antimalarial drugs. This makes the challenge in an effort to effective malaria treatment. One way to use natural resources through the plant potentially efficacious in maintaining health and treating disease. The use of plants in medicine has been started since the days fished by our ancestors. Echinacea which is believed to have immunomodulatory effects that can increase the activity of macrophages. Microglia are macrophage form contained in the brain tissue that serves to phagocytosis of damaged tissue and foreign substances on the brain. This study aimed to determine the effect of Echinacea extracts on the activity of microglia in the brain histological mice before infected with Plasmodium berghei and parasite dispersal rate in the brains of mice This type of study is a method of the post test ± control group design. Performed by observing histologycal brain in the mice which has infected by Plamodium berghei after previously awarded Echinacea extract for 10 days to boost the immune system of mice. Echinacea as tested dose 2.45 mg for the first treatment, Echinacea 4.875 mg for the second treatment and Echinacea 9.75 mg for the third treatment meanwhile Phyllantus niruri as positive control 2.028 mg. Subjects were 40 male Swiss mice were divided into 5 groups. The observation of the activity of microglia and counting parasites in the brains of mice were performed using SPSS software version 17. The results showed there were significant differences in the provision of Echinacea in mice by increasing the activity of microglia which has tested by one way ANOVA test p = 0.003 (p <0.05). On the spread of parasites in the brains of mice results obtained through Kruskal Wallis test p = 1.00 (p> 0.05), it means there is no significant difference in the rate of spread of Echinacea administration parasites in the brain of mice.